Weight loss from Wegovy sustained for up to four years, trial shows

Enlarge / Wegovy is an injectable prescription weight loss medicine that has helped people with obesity. Getty | Michael Siluk

A large, long-term trial of the weight-loss medication Wegovy (semaglutide) found that people tended to lose weight over the first 65 weeks on the drug—about one year and three months—but then hit a plateau or “set point.” But that early weight loss was generally maintained for up to four years while people continued taking the weekly injections.

The findings, published Monday in Nature Medicine, come from a fresh analysis of data from the SELECT trial, which was designed to look at

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