Like a ghost
To test the tool, they had convenient examples: the Neanderthal and Denisovan sequences we’ve already identified in the human genome. If TRACE couldn’t pick those out, it wouldn’t find anything else useful. The development of ancestral recombination graphs is still a work in progress, so the researchers used two different tools to generate them and stuck with the one that produced the best results. The combination produced a very low false discovery rate (less than a quarter of a percent) while having an accuracy of over 90 percent.
In another demonstration, the researchers performed the analysis on African populations, which only received Neanderthal and Denisovan DNA
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