BA.4/BA.5 will soon be dominant in the US. Here’s what that means

Enlarge / A COVID-19 testing tent stands in Times Square on April 27, 2022, in New York City. Getty | Spencer Platt

Omicron coronavirus subvariants BA.4 and BA.5 are now accounting for an estimated 35 percent of US cases, according to the Centers for Disease Control and Prevention. The subvariants are on a course to reach dominance at a faster clip than the subvariants before them, including the current reigning subvariant, BA.2.12.1, which is now in decline.

The pair—which share the same mutations in their SARS-CoV-2 spike proteins but have differences elsewhere in their genomes—are expected to reach dominance “in

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